Joint Cap Joint Pain Tablet

Additional Information

Rheumatoid arthritis is a chronic systemic autoimmune disease which primarily involves synovial joint pain, immobility, and stiffness. RA exhibits extreme variation, ranging from a mild, self-limiting disease to a rapidly progressive arthritis with extra-articular manifestations. Rheumatoid arthritis patients use a variety of different treatment options to reduce inflammation and alleviate pain and stiffness. With chronic involvement of arthritis there is cartilage damage and collagen synthesis impairments. Articular cartilage is a protective cushion that enables knees and other joints to move smoothly and provides a bouncy cushion between bones at the joints. Osteoclastic bone resorption is another characteristic feature of arthritis besides inflammation, which wears away bones and leads to pain, stiffness and impaired movement.

Molecular pathways involving the receptor activator of NF-Kappa B (RANK) and its ligand, RANK ligand (RANKL), play a critical role in regulating osteoclastogenesis in the joints in RA. The synovium is a thin delicate lining that serves several important functions. Synovial cells synthesize joint lubricants, such as hyaluronic acid, as well as collagens, that constitute the structural framework of the synovium. Arthritis involves the breakdown of cartilage, which protects a joint, allowing it to move smoothly. The pathology of the disease process often leads to the destruction of articular cartilage and the alkalosis of the joints. 3-O-acetyl-11-keto-β-boswellic acid (AKBA) possesses the most potent 5-LOX inhibitory activity. B. serrata extracts have shown significant efficacy and safety in the treatment of rheumatoid arthritis.

Arthritic joint affecting subchondral bone and cartilage is due to degradation of cartilage is principally mediated by enzymes like matrix metalloproteinases (MMPs), hyaluronidases (HAase), aggrecanases and exoglycosidases. These enzymes act upon collagen, hyaluronan and aggrecan of cartilage respectively, which would in turn activate bone deteriorating enzymes like cathepsins and tartrate resistant acid phosphatases (TRAP). Tamarind seed extracts present in JOINTCAP exhibited cartilage and bone protecting nature by inhibiting the elevated activities of MMPs, HAase, exoglycosidases, cathepsins and TRAP. It also mitigated the augmented levels of inflammatory mediators like interleukin (IL)-1β, tumor necrosis factor-α, IL-6, IL-23 and cyclooxygenase-2.

JOINTCAP regenerates the damaged cartilage with the help of supplements for cartilage formation like hyaluronic acid, collagen, and Chondroitin. It has the potential to re-grow cartilage in the knees of patients with osteoarthritis. In addition, JOINTCAP also contains Calcium Hydroxyapatite, a biomaterial, which is osteoconductive in nature and has physiochemical properties similar to the mineral constituents of bone and is therefore used widely in bone repairs and bone healing. Calcium hydroxyapatite as an organic form of calcium and phosphate helps in bone restoration and provides strength to damaged bones.