Diabiome Anti Diabetic Probiotics

Additional Information

The widespread use of antibiotics and the transition to a highly processed diet lacking fibre and other prebiotics, has altered our natural gut microflora. The altered flora, or dysbiosis, is linked to metabolic diseases such as diabetes, obesity, hypertension, and dyslipidaemia. Dietary intolerance (excessive fat, refined carbohydrate or fructose) alters the gastrointestinal microbiota. Gut bacteria is an important determinant of susceptibility to obesity and related metabolic diseases.

The alteration in the gut microbiota has recently been recognized as a key environmental factor resulting in metabolic diseases, such as type 2 diabetes. Gut bacteria could also affect obesity by promoting a chronic inflammatory status. An altered flora followed by dysbiosis affects carbohydrate metabolism. The gut microbiome of a diabetic person is found to be different from that of a healthy one. In a human study, it was found that the amount of Firmicutes bacteria is lower, whereas the number of Bacteroides and Proteobacteria is higher in the gastrointestinal tract of patients with type 2 diabetes compared to that of non-diabetic persons. Following innovative dietary strategies, it seems possible to maintain euglycemia by normalizing the altered microbiome, and to prevent long-term micro- and macrovascular complications of type 2 diabetes.

Probiotics have been reported to have a positive impact on the metabolic control in diabetes and this has been proven by their ability to lower fasting glucose and insulin levels. Whole bacteria, as well as their products and metabolites, undergo increased translocation through the gut epithelium to the circulation, due to degraded tight junctions and the consequent increase in intestinal permeability that culminates in inflammation and insulin resistance. Probiotics significantly reduced total cholesterol, triglyceride levels, CRP levels, HbA1c levels, fasting plasma glucose levels, fasting insulin, and blood pressure together with the increase of the HDL levels.

For glycemic control, a combination of probiotics and prebiotics in the symbiotics supplementation is more effective than probiotics alone. The carbohydrate prebiotics such as insulin, fructo-oligosaccharide (FOS) and galacto-oligosaccharide (GOS), linear chains connected with β glycosidic bonds are resistant to human enzymatic digestion in the small intestine. As such, the consumption of these compounds has no acute effect on blood glucose levels or stimulation of insulin secretion. Fiber consumption is inversely associated with body weight, body fat, diabetes and insulin resistance. The use of functional foods for the preven­tion and management of diseases has steadily increased over the last few decades as a means of advancing health and emo­tional well-being.

There have been many cas­es where patients obtained relief from symptoms related to chronic illnesses as an aftermath of conventional medication. Prebiotics can be helpful for people with diabetes because they encourage the growth of potentially beneficial bacteria. Increasing fiber content in your diet may also help you cultivate a diverse microbiome and potentially improve symptoms of diabetes. The phenolic content and low glycemic index of dietary fiber makes it advanta­geous for diabetic patients. Fiber also affects satiety and is related to changes in the appetite-related gut hormones. A number of peptides, including glucagon-like peptide-1 (GLP-1), have been shown to increase satiety and decrease energy intake. FOS is mainly known for its ability to improve host health as it stimulates the growth of some beneficial bacteria, such as the Bifidobacteria. FOS supplementation in the diet can be a possible strategy for reducing blood glucose.