Gastrezz Acidity, Gastritis, Acid Reflux Tablet

Additional Information

Gastritis is an inflammation of the stomach lining causing belly pain, indigestion (dyspepsia), bloating and nausea. It causes pain, discomfort, burning feeling in chest or stomach, burping, bloating, acid reflux, heartburn, nausea and/or vomiting. Gastritis is irritation, inflammation, or erosion of the stomach lining. The inflammation in gastritis is mostly associated with the same bacterium that is responsible for causing most stomach ulcers.

There are two categories of gastritis depending on the cause of the disease. There is erosive gastritis, for which the common causes are stress, alcohol, some drugs, such as Aspirin and other nonsteroidal anti-inflammatory drugs (NSAIDs). Helicobacter pylori is an opportunistic pathogen associated with the pathogenesis of chronic gastritis, peptic ulcers, and gastric cancer, and is a global health concern. Common causes include infection with H. pylori and use of nonsteroidal anti-inflammatory drugs (NSAIDs) which can induce inflammation, peptic ulcers and possibly mucosal atrophy.

Acute erosive gastritis typically involves a discrete foci of surface necrosis due to damage to mucosal defenses.
Gastritis occurs when something damages or weakens the stomach lining because of medication, bile reflux, alcohol abuse, stress and bacterial infection. The continuous mucosal injury due to long-standing H. pylori infection, leads to atrophy of the stomach. This continuous pathological process results in erosion or ulceration of the mucosa leading to the destruction of the glandular layer.

Gastric ulcers and related symptoms such as acidity and acid reflux is a global disease in which there are unmet needs related to current treatments in terms of efficacy, safety. Triple therapy (proton pump inhibitor, clarithromycin and amoxicillin or an imidazole) is the first-line treatment for Helicobacter pylori infection. However, the effectiveness of triple therapy is decreasing due to the increase in antibiotic resistance.

Essential oils can act as antimicrobial agents against H pylori. The importance and usefulness of the constituents of essential oils has been explored and they have been found to be promising agents in the management of gastric ulcers.
GASTREZZ is a unique combination of essential oils such as Menthol, Carvacrol, Tree tea oil, thyme oil, peppermint oil and citral oil which have been proven to have antibacterial properties against H pylori infection. Peppermint oil is not only antispasmodic but it also relieves stomach cramps and bloating. Use of different phytochemicals such as EGCG, attenuated the synthesis of the proinflammatory mediator, hydroxyeicosatetraenoic acid, antioxidative and antibacterial actions, and shows protective mechanism of EGCG against H. pylori induced cytotoxicity in gastric epithelial cells. Licorice extract acts as an antacid and reduces the free and total HCl levels in the stomach.

Glycyrrhizin inhibits gastric secretion, reduces inflammatory mediators and protects the gastric mucosa. Curcumin shows anti-inflammatory activity which inhibits the expression of COX-1, COX-2, lipoxygenase, TNFa, IFN-g , iNOS and NFkB activation. Marshmallow reduces oxidative stress, inhibits histamine release and decreases inflammation that helps reduce ulcer formation.

Herbs like Alfalfa, Chamomile, Dandelion, Slippery Elm and Fennel with the Bach Flower Remedies Vine, Agrimony, Larch and Walnut normalise the digestive system function and support the healing of the gastric mucosa. Agrimony is useful in severe chest pain or burning sensation, acid reflux, diarrhea, vomiting and nausea. Chamomile is a digestive relaxant and has been used to treat various gastrointestinal disturbances including flatulence, indigestion, diarrhea, anorexia, motion sickness, nausea and vomiting. A combination of essential oils and phytochemicals used in GASTREZZ helps in changing the gut microenvironment for the correction of pathophysiology of gastritis and the associated symptoms.